Key result
MDV-inoculated chickens susceptible to transient paralysis exhibited widened extracellular spaces, intramyelinic oedema, endothelial cell hypertrophy, and signs of vasculitis.
Ultrastructural findings in MDV-induced transient paralysis in chickens suggest vasculitis and increased coated micropinocytotic vesicles as potential mechanisms for altered blood-brain-barrier and vasogenic edema.
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These changes associate with MDV transient paralysis; hypothesis-generating and leaves open causal role or therapeutic relevance.
Swayne et al. (1989) studied Marek's disease virus-induced transient paralysis. Marek's disease virus (MDV) inoculation vs. TP-resistant chickens was evaluated on Ultrastructural changes of the central nervous system. MDV-inoculated chickens susceptible to transient paralysis exhibited widened extracellular spaces, intramyelinic oedema, endothelial cell hypertrophy, and signs of vasculitis.
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