Key result
Postoperative diagnosis of liposarcoma among presumed lipomas was associated with male sex (87.5% vs 38.9%) and the presence of nonfatty septa on imaging (71.4% vs 20.0%) compared to true lipomas.
Why the study?
What are the characteristic clinical and imaging features of liposarcomas preoperatively misdiagnosed as lipomas?
Observational (n=637)
No
What are the characteristic clinical and imaging features of liposarcomas preoperatively misdiagnosed as lipomas?
Absolute Event Rate: 71.4% vs 20%
Male sex, large tumor size, and thick internal septa on imaging are important predictors of malignancy in lipomatous tumors preoperatively diagnosed as lipomas.
May heighten suspicion for malignancy in select presumed lipomas; leaves open whether demographics and imaging should alter preoperative algorithms.
BACKGROUND: On rare occasions, a lesion preoperatively diagnosed as a lipoma is ultimately diagnosed as a liposarcoma. It is important to differentiate liposarcomas from lipomas preoperatively. OBJECTIVE: To examine characteristic features of liposarcomas preoperatively diagnosed as lipomas. METHODS: Patients (n = 637) who underwent resection of tumors preoperatively diagnosed as lipomas from January 2006 to October 2016 were retrospectively reviewed. RESULTS: Based on pathological examination, 8 of 637 lesions were diagnosed as liposarcomas postoperatively. All the liposarcomas were well-differentiated liposarcomas. The rate of male patients was higher (87.5% vs 38.9%) and the size of tumors was larger (8.75 vs 4.64 cm) in these cases than in accurately diagnosed lipoma cases. On imaging, nonfatty septa were more frequently observed (71.4% vs 20.0%) and were thicker (2.22 vs 1.33 mm) than in true lipoma cases. CONCLUSION: If the patient with a lipomatous tumor is male and the tumor is large, we should consider the possibility of it being a liposarcoma. A thick internal septum in the image findings is a good predictor of malignancy.
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Sato et al. (2018) conducted an observational in Tumors preoperatively diagnosed as lipomas (n=637). Postoperative diagnosis of liposarcoma vs. Accurately diagnosed lipoma was evaluated on Presence of nonfatty septa on imaging. Postoperative diagnosis of liposarcoma among presumed lipomas was associated with male sex (87.5% vs 38.9%) and the presence of nonfatty septa on imaging (71.4% vs 20.0%) compared to true lipomas.
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