Key result
Healthy adult cohort defines 99th-percentile plasma H-FABP reference limit at 5.6 ng/mL.
Why the study?
There is a paucity of data on circulating levels of heart-type fatty acid-binding protein in the general population to establish reference values for early AMI diagnosis.
What are the plasma reference values of heart-type fatty acid-binding protein (H-FABP) in healthy subjects?
Cross-Sectional (n=443)
Yes
What are the plasma reference values of heart-type fatty acid-binding protein (H-FABP) in healthy subjects?
Establishes the 99th centile reference value for H-FABP at 5.6 ng/mL in healthy subjects aged 41-69 years, which may aid in the early diagnosis of acute myocardial infarction.
Provides foundational H-FABP reference data in middle-aged adults; leaves open diagnostic utility for AMI until prospectively validated.
More rapid triaging of patients suspected for acute myocardial infarction (AMI) is needed to facilitate early initiation of appropriate therapy in patients with AMI and to exclude low-risk patients who can safely be sent home. Heart-type fatty acid-binding protein (H-FABP) is established to be the earliest available plasma marker for AMI diagnosis. There is a paucity of data on circulating levels of H-FABP in the general population. In this study we applied a H-FABP immunoassay with improved analytical performance to assess plasma H-FABP reference values in a relatively large group (n = 443) of healthy subjects aged 18-69 y. Mean (±SD) plasma H-FABP concentration was 1.7 ± 0.9 ng/mL, with somewhat higher values found in males than in females. Plasma H-FABP also increases with age, as previously reported. The 99th centile was obtained for subjects aged 41-69 years and amounted to 5.6 ng/mL.
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Glatz et al. (2013) conducted a cross-sectional in Healthy (reference value establishment) (n=443). Plasma H-FABP was evaluated on 99th centile of plasma H-FABP in subjects aged 41-69 years. The 99th centile reference value for plasma H-FABP in healthy subjects aged 41 to 69 years was established at 5.6 ng/mL.
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