The antitumour prodrug temozolomide 1 undergoes ring-opening in deuteriated phosphate buffer; deuterium incorporation into the methyl group transferred from the reactive species 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC)2has been monitored by observing D–H and P–H couplings in the NMR spectra of the products.
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Wheelhouse et al. (1993) studied this question.