Key result
Genetics and cardiac MRI fibrosis characterization improve primary prevention ICD selection over LVEF alone.
Why the study?
Does incorporating genetic analysis and MRI characterization of myocardial fibrosis improve the selection of patients with cardiomyopathies for primary prevention ICD compared to LVEF alone?
Does incorporating genetic analysis and MRI characterization of myocardial fibrosis improve the selection of patients with cardiomyopathies for primary prevention ICD compared to LVEF alone?
Incorporating genetic analysis and MRI for myocardial fibrosis characterization improves risk stratification for primary prevention ICDs beyond LVEF alone.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for refined ICD selection in cardiomyopathies; prospective trials needed before changing LVEF-based practice.
The selection of patients eligible for implantable cardioverter defibrillator (ICD), in primary prevention, is a critical moment in the management of the patients with cardiomyopathies as it needs a right balance of the patients' arrhythmic risk and the risks related to the implantation, as well as the device costs. Several data indicate that left ventricular ejection fraction alone is not a sufficient criterion for a proper identification of patients who could benefit most from ICD. Numerous findings show that genetic analysis and characterization of myocardial fibrosis with magnetic resonance imaging allow an important improvement of this process.
No takes yet. Share an insight, caveat, or question.
Vittoria Rizzello (2022) conducted a review in Cardiomyopathies. Genetic analysis and magnetic resonance imaging vs. Left ventricular ejection fraction alone was evaluated. Genetic analysis and characterization of myocardial fibrosis with magnetic resonance imaging improve the selection of patients with cardiomyopathies for primary prevention ICDs compared to LVEF alone.
Synapse has enriched 10 related papers. Consider them for comparative context: