January 17, 2005HypertensionOpen Access

Different Involvement of Extracellular Matrix Components in Small and Large Arteries During Chronic NO Synthase Inhibition

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Why the study?

Does MMP inhibition with doxycycline prevent eutrophic remodeling in small arteries during chronic NO synthase inhibition in rats?

Population

Rats receiving N-nitro-L-arginine methyl ester in their drinking water to induce chronic NO synthase…

Comparison

L-NAME for up to 28 days, with an additional… vs Control rats (baseline values) and L-NAME alone.

Design

Preclinical

Follow-up

28 days

Authors

CBCéline BouvetUniversité de Montréal LGLiz-Ann GilbertUniversité de Montréal DGDaphné GirardotCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

MMPs drive large- but not small-artery remodeling in this model; leaves open differential targeting and human relevance.

Structured PICO

Does MMP inhibition with doxycycline prevent eutrophic remodeling in small arteries during chronic NO synthase inhibition in rats?

Population

Rats receiving N(omega)-nitro-L-arginine methyl ester (L-NAME; 50 mg/kg per day) in their drinking water to induce chronic NO synthase inhibition.

Intervention

L-NAME (50 mg/kg per day) for up to 28 days, with an additional group receiving the nonselective MMP inhibitor doxycycline (30 mg/kg per day) on days 7, 14, and 28.

Comparator

Control rats (baseline values) and L-NAME alone.

Outcome

Arterial remodeling (media/lumen ratio, cross-sectional area) and extracellular matrix component levels (MMP-2 activity, tenascin-C, thrombospondin) in mesenteric arteries and aorta.surrogate

Matrix metalloproteinases play a crucial role in large artery hypertrophic remodeling but appear less involved in small artery eutrophic remodeling during chronic NO synthase inhibition.

Cite This Study

Bouvet et al. (2005) studied this question.

synapsesocial.com/papers/6ab5fb1b839ad79bfd4496c2 https://doi.org/10.1161/01.hyp.0000154680.44184.01

Topics

Hypertension management

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Different Involvement of Extracellular Matrix Components in Small and Large Arteries During Chronic NO Synthase Inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Different Involvement of Extracellular Matrix Components in Small and Large Arteries During Chronic NO Synthase Inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider