Key result
Obesity with eccentric LV hypertrophy is linked to impaired LV diastolic filling, prolonging deceleration half-time ~26%.
Why the study?
The left ventricular diastolic filling pattern in obese subjects with eccentric LV hypertrophy was not well characterized and needed comparison with normal and hypertensive subjects.
Does eccentric LV hypertrophy of obesity cause abnormal LV diastolic filling compared to normal controls and concentric LV hypertrophy of hypertension?
Comparison
Obese eccentric LV hypertrophy vs normal controls and hypertensive concentric LV hypertrophy
Design
Cross-sectional echocardiographic study
Authors
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May indicate similar diastolic impairment in obese eccentric LVH as hypertensive concentric LVH; hypothesis-generating for echo interpretation adjustments.
Cross-Sectional (n=39)
Does eccentric LV hypertrophy of obesity cause abnormal LV diastolic filling compared to normal controls and concentric LV hypertrophy of hypertension?
Eccentric LV hypertrophy in obesity causes abnormal LV diastolic filling patterns similar to those seen in concentric LV hypertrophy of hypertension.
Chakko et al. (1991) conducted a cross-sectional in Eccentric left ventricular hypertrophy of obesity (n=39). Obesity with eccentric LV hypertrophy vs. Normal control subjects and nonobese hypertensive patients with concentric LV hypertrophy was evaluated on Left ventricular diastolic filling pattern. Obesity with eccentric LV hypertrophy was associated with abnormal LV diastolic filling compared to normal controls, including prolonged deceleration half-time (108 vs 86 ms, P<0.01).
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