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April 1, 1995American Journal of Hypertension

Isovolumic relaxation time was prolonged in hypertensive obese (85±22 msec) and normotensive obese (85±21 msec) compared to normotensive normal-weight controls (59±14 msec, p<0.0001), independently of age, BP, and R-R time.

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Why the study?

Does obesity influence left ventricular filling in patients with essential hypertension?

Population

86 subjects including 18 hypertensive obese patients, 31 normotensive obese subjects, and 37 normotensive…

Comparison

Obesity with or without essential hypertension vs Normotensive normal-weight controls

Design

Cross-sectional

Authors

GMGianfrancesco Mureddu

Discussion

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Overview

Obesity may drive LV filling abnormalities more than hypertension alone; this cross-sectional finding leaves open whether weight loss improves diastolic function.

Structured PICO

Does obesity influence left ventricular filling in patients with essential hypertension?

P
Population
86 subjects including 18 hypertensive obese patients (OH), 31 normotensive obese subjects (ON), and 37 normotensive normal-weight controls (NN).
I
Intervention
Obesity with or without essential hypertension
C
Comparator
Normotensive normal-weight controls
O
Outcome
Doppler left ventricular diastolic flow parameters (isovolumic relaxation time, transmitral peak E velocity, E deceleration time, atrial filling fraction)surrogate

Left ventricular filling abnormalities in obese patients with hypertension are primarily driven by obesity rather than hypertension alone.

Cite This Study

Gianfrancesco Mureddu (1995) studied this question.

synapsesocial.com/papers/6a70e7b331a3df82432927a0https://doi.org/10.1016/0895-7061(95)98017-s
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Ventricular Filling in Arterial Hypertension1997 · 63 citations
  2. 2Influence of Mild to Moderate Obesity on Left Ventricular Stress Filling Pattern in Hypertension.1998 · 8 citations
  3. 3Abnormal left ventricular diastolic filling in eccentric left ventricular hypertrophy of obesity1991 · 103 citations
  4. 4Influence of Obesity on Left Ventricular Midwall Mechanics in Arterial Hypertension1996 · 54 citations
  5. 5Subclinical Regional Left Ventricular Dysfunction in Obese Patients With and Without Hypertension or Hypertrophy2010 · 18 citations