October 21, 2010Obesity
Obese groups had decreased longitudinal and radial systolic myocardial peak velocities (S') and early diastolic myocardial peak velocity (E'), with greater variability in basal E' (19 ± 11 vs 11 ± 7, P < 0.001) compared to non-obese groups.
Why the study?
Does obesity impact regional left ventricular systolic and diastolic function in patients with or without hypertension or hypertrophy?
Population
120 individuals without heart failure, mean age 42 ± 6 years, 60 females, divided into 6 groups of 20…
Design
Cross-sectional
Authors
Discussion
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Overview
Suggests subclinical LV impairment in obesity; hypothesis-generating and requires prospective validation before informing practice.
Structured PICO
Does obesity impact regional left ventricular systolic and diastolic function in patients with or without hypertension or hypertrophy?
P
Population
120 individuals without heart failure, mean age 42 ± 6 years, 60 females, divided into 6 groups of 20 patients based on obesity (BMI ≥30 kg/m2), hypertension (BP ≥ 140/90 mm Hg), and hypertrophy.
C
Comparator
Non-obese individuals with or without hypertension and hypertrophy
O
Outcome
Systolic and diastolic regional left ventricular function assessed by standard and pulsed-wave tissue Doppler imaging (TDI) echocardiography and heterogeneity indexsurrogate
Obesity is associated with subclinical regional left ventricular systolic and diastolic dysfunction, which is exacerbated by the presence of hypertension and hypertrophy.
Cite This Study
Santos et al. (2010) studied this question.