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August 1, 1996Hypertension

Influence of Obesity on Left Ventricular Midwall Mechanics in Arterial Hypertension

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Why the study?

Does obesity worsen left ventricular midwall mechanics in patients with arterial hypertension?

Population

737 adults, comprising 156 normotensive normal-weight, 94 normotensive overweight-to-obese, 263 hypertensive…

Comparison

Overweight or obesity (body mass index > 30 kg/m2) vs Normal weight

Design

Cross-sectional

Authors

GSGiovanni de SimoneRDRichard B. DevereuxGMGian Francesco Mureddu

Discussion

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Overview

High BMI associates with altered midwall LV performance in hypertension; leaves open whether obesity impairs function or requires Starling compensation.

Structured PICO

Does obesity worsen left ventricular midwall mechanics in patients with arterial hypertension?

P
Population
737 adults, comprising 156 normotensive normal-weight, 94 normotensive overweight-to-obese, 263 hypertensive normal-weight, and 224 hypertensive overweight-to-obese individuals.
I
Intervention
Overweight or obesity (body mass index > 30 kg/m2)
C
Comparator
Normal weight
O
Outcome
Left ventricular midwall shortening-circumferential end-systolic stress relations measured by echocardiographysurrogate

While obesity does not directly depress midwall left ventricular systolic performance in hypertension, it requires compensatory use of the Starling reserve (increased LV end-diastolic volume) to maintain normal function.

Cite This Study

Simone et al. (1996) studied this question.

synapsesocial.com/papers/6a7f347e7caf4fb4be694a34https://doi.org/10.1161/01.hyp.28.2.276
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Ventricular Filling in Arterial Hypertension1997 · 63 citations
  2. 2Influence of Mild to Moderate Obesity on Left Ventricular Stress Filling Pattern in Hypertension.1998 · 8 citations
  3. 3Impact of Obesity on Left Ventricular Mass and Function in Subjects With Chronic Volume Overload2007 · 15 citations
  4. 4Subclinical Regional Left Ventricular Dysfunction in Obese Patients With and Without Hypertension or Hypertrophy2010 · 18 citations
  5. 5An echocardiographic study of the effect of obesity on systolic and diastolic functions of the left ventricle in hypertensive adults2022 · 1 citations