Key result
Medication nonadherence leads to recurrent DKA, severe hypertriglyceridemia, and 2 acute pancreatitis episodes.
Case Report (n=1)
This is the first reported case of a patient experiencing recurrent acute pancreatitis induced by diabetic ketoacidosis and severe hypertriglyceridemia.
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Alerts clinicians to non-compliance risks in recurrent pancreatitis; hypothesis-generating case extends rare etiology literature but leaves generalizability open.
This case report describes the recurrence of diabetic ketoacidosis (DKA) leading to hypertriglyceridemia-induced pancreatitis. Hypertriglyceridemia is present in 2-5% of patients with diabetic ketoacidosis. Hypertriglyceridemiainduced pancreatitis occurs in up to 4% of patients with diabetic ketoacidosis and is a well-reported complication. This is the first case report to the author's knowledge, where the same patient had two separate episodes of acute pancreatitis that have been attributed to diabetic ketoacidosis and resultant severe hypertriglyceridemia, etiology determined to be medication non-compliance. DKA and acute pancreatitis can co-exist, and hypertriglyceridemia has been the predominant pathogenetic link between the two conditions. We also describe the pathophysiology and treatment of hyper-triglyceridemia-induced pancreatitis in diabetic ketoacidosis.
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TIPERNENI et al. (2022) conducted a case report in Diabetic ketoacidosis and hypertriglyceridemia-induced pancreatitis (n=1). Diabetic ketoacidosis and severe hypertriglyceridemia was evaluated on Recurrence of acute pancreatitis. Medication non-compliance led to recurrent diabetic ketoacidosis and severe hypertriglyceridemia, resulting in two separate episodes of acute pancreatitis in the same patient.
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