Key result
GANGLIA-AF compares stand-alone GP ablation to standard PVI for paroxysmal AF without reporting quantitative results.
Why the study?
The autonomic nervous system via the ganglionated plexus contributes to AF arrhythmogenesis, but the long-term outcomes of GP ablation as sole therapy for paroxysmal AF were not established.
RCT
Single-blind
randomized
Yes
Answers are grounded in this paper and cite their sources.
No GANGLIA-AF outcomes reported; leaves open whether GP ablation improves outcomes versus PVI in paroxysmal AF.
The autonomic nervous system, through the ganglionated plexus (GP), is known to contribute to the arrhythmogenesis of atrial fibrillation (AF). The GANGLIA-AF trial was a prospective, multicenter, randomized, single-blinded study (NCT02487654) randomizing paroxysmal AF patients to either stand-alone left atrial ectopy-triggering GP (ET-GP) ablation or standard pulmonary vein isolation (PVI) only.1 The trial was unique in that it performed detailed mapping of the left atrium, surveying for sites that triggered atrial ectopy or AF by high-frequency, high-output stimulation within the local atrial refractory period.
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Kay et al. (2024) conducted an RCT in paroxysmal atrial fibrillation. stand-alone left atrial ectopy-triggering GP (ET-GP) ablation vs. standard pulmonary vein isolation (PVI) only was evaluated. The GANGLIA-AF trial compared stand-alone left atrial ectopy-triggering GP ablation to standard PVI for paroxysmal atrial fibrillation, but the abstract reports no quantitative results.
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