Key result
Left inferior pulmonary vein enlargement is linked to ~97% higher stroke risk in NVAF.
Why the study?
The association between pulmonary vein dilatation and stroke in non-valvular atrial fibrillation patients remains unknown.
Is pulmonary vein and left atrial appendage enlargement associated with stroke in patients with non-valvular atrial fibrillation?
Comparison
Non-valvular AF patients with stroke vs non-valvular AF patients without stroke and controls
Design
Case-control study
Authors
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PV enlargement may flag higher stroke risk in non-valvular AF; hypothesis-generating and needs prospective validation before guiding anticoagulation.
Case-Control (n=414)
Blinded to study groups
No
Is pulmonary vein and left atrial appendage enlargement associated with stroke in patients with non-valvular atrial fibrillation?
Odds Ratio: 1.97 (95% CI 1.41–2.75)
Absolute Event Rate: 2.3% vs 1.8%
p-value: p=<0.001
Enlargement of the left-sided pulmonary veins and left atrial appendage is independently associated with non-hemorrhagic stroke in patients with non-valvular atrial fibrillation.
Lee et al. (2014) conducted a case-control in Non-valvular atrial fibrillation (n=414). Non-valvular atrial fibrillation with stroke vs. Non-valvular atrial fibrillation without stroke was evaluated on Left inferior pulmonary vein (LIPV) orifice area as an independent predictor of stroke (OR 1.97, 95% CI 1.41-2.75, p=<0.001). In patients with non-valvular atrial fibrillation, enlargement of the left inferior pulmonary vein was an independent predictor of stroke (OR 1.97), with left-sided structures showing more significant remodeling than right-sided structures.
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