Comparison of Non-Invasive Methods for the Detection of Coronary Atherosclerosis
Key result
Calcium score and low HDL-C are independently associated with greater coronary artery disease extent.
- n=100
Why the study?
Non-invasive detection of coronary atherosclerosis is critical for prevention, but the correlation of various non-invasive indicators with coronary disease extent is unclear.
Do non-invasive indicators such as calcium score and lipid profiles correlate with the extent of coronary artery disease assessed by coronary angiography in patients referred for angiography?
Population
100 consecutive patients referred for coronary angiography, mean age 55.1 +/- 10.7 years, 55% men and 45% women
Design
Prospective observational study
Authors
Discussion
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Member takes
Implication
May inform non-invasive CAD assessment; hypothesis-generating and requires prospective validation before practice change.
Study Design
Type
Observational (n=100)
Structured PICO
Do non-invasive indicators such as calcium score and lipid profiles correlate with the extent of coronary artery disease assessed by coronary angiography in patients referred for angiography?
P
Population
100 consecutive patients (mean age 55.1 years, 45% women) undergoing coronary angiography, excluding those with acute coronary syndrome, renal insufficiency, collagen disease, or cancer.
E
Exposure
Non-invasive indicators of coronary atherosclerosis (classical risk factors, hs-CRP, carotid intima-media thickness, endothelial function, ankle-brachial index, calcium score by computed tomography, non-HDL cholesterol, and TG/HDL-c ratio)
C
Comparator
Conventional coronary angiography (Friesinger index)
O
Outcome
Correlation of non-invasive indicators with the extent of coronary disease assessed by the Friesinger index from conventional coronary angiographysurrogate
Calcium score, HDL-c, and TG/HDL-c ratio can non-invasively predict the presence and extent of coronary artery disease.
Cite This Study
Bampi et al. (2009) conducted an observational in Coronary Atherosclerosis (n=100). Non-invasive indicators of coronary atherosclerosis was evaluated on Extent of coronary disease assessed by the Friesinger index. Non-invasive methods, especially calcium score and low HDL-c levels, significantly correlated with the extent of coronary artery disease assessed by the Friesinger index on multivariate analysis.