Key result
Combined metabolic syndrome and diabetes is linked to ~130% higher odds of coronary artery calcium.
Why the study?
Data suggest that only diabetes mellitus subjects with metabolic syndrome are at increased coronary risk, but the individual and joint associations with atherosclerosis are unclear.
Are metabolic syndrome and diabetes mellitus independently and jointly associated with increased atherosclerosis in a general population?
Population
2,735 participants from the Dallas Heart Study, median age 44 years, 68% non-white, 55% women
Comparison
Metabolic syndrome and/or diabetes mellitus vs neither metabolic syndrome nor diabetes mellitus
Design
Observational population-based study
Authors
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May signal need for enhanced surveillance in comorbid patients; hypothesis-generating and should not yet change practice.
Observational (n=2,735)
Are metabolic syndrome and diabetes mellitus independently and jointly associated with increased atherosclerosis in a general population?
Odds Ratio: 2.3 (95% CI 1.6–3.2)
Absolute Event Rate: 44.7% vs 16.6%
p-value: p=<0.0001
Both metabolic syndrome and diabetes mellitus are independently associated with an increased prevalence of atherosclerosis, with the highest risk observed in individuals having both conditions.
Chen et al. (2008) conducted an observational in Metabolic syndrome, diabetes mellitus, and atherosclerosis (n=2,735). Concurrent metabolic syndrome and diabetes mellitus vs. Neither metabolic syndrome nor diabetes mellitus was evaluated on Coronary artery calcium (CAC) detected by electron-beam computerised tomography (OR 2.3, 95% CI 1.6-3.2, p=<0.0001). Concurrent metabolic syndrome and diabetes mellitus was associated with the highest prevalence of coronary artery calcium compared to neither condition (adjusted OR 2.3; 95% CI 1.6-3.2).
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