Key result
Elevated BNP and older age are linked to worsening heart failure within 30 days.
Why the study?
Inflammatory and immune system activation with increased cytokines and inflammatory proteins during acutely decompensated heart failure may influence pathogenesis and outcomes, but their roles require evaluation.
Do circulating biomarkers of neurohormonal and inflammatory activation predict clinical outcomes in patients with acute heart failure?
Cohort (n=112)
Do circulating biomarkers of neurohormonal and inflammatory activation predict clinical outcomes in patients with acute heart failure?
Circulating markers of inflammation and neurohormonal activation, particularly BNP, CRP, IL-6, and TPA, may be useful in predicting prognosis and mortality in patients with acute heart failure.
No takes yet. Share an insight, caveat, or question.
May support biomarker risk stratification in AHF; leaves open whether inflammation is a causal therapeutic target.
Milo‐Cotter et al. (2011) conducted a cohort in Acute Heart Failure (n=112). Elevated neurohormonal and inflammatory biomarkers was evaluated on Worsening heart failure by day 30 and 180-day mortality. Elevated levels of BNP and older age were independently associated with worsening heart failure by day 30 in patients with acute heart failure.
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