Pulmonary Artery Pressure-Guided Heart Failure Management Reduces Hospitalizations in Patients With Chronic Kidney Disease

Figures

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  Figure 1.. Composition of cohorts used to examine heart failure outcomes and renal progression hypotheses.

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  Figure 2.. Outcomes across eGFR quartiles. A, Heart failure hospitalization (HFH) rates 12 months before implantation compared with 12 months after implantation based on estimated glomerular filtration rate (eGFR) quartiles (n=1200). Change in pulmonary artery (PA) pressures over time using an area under the curve analysis, based on eGFR quartiles in the entire population of 1200 enrolled patients (B). C, Depicts Kaplan-Meier survival analysis of all patients stratified by eGFR quartile at baseline. Kaplan-Meier survival expressed as % (95% CI). EPPY indicates events per patient year. *Includes all Clinical Events Committee (CEC) adjudicated heart failure hospitalizations with an admission date on the date of implant and through 390 days prior to the date of implant. †Includes all CEC adjudicated heart failure hospitalizations with an admission date after the implant procedure discharge date through 390 days after the date of implant. ‡Hospitalization rate is an annualized rate estimated from the Andersen-Gill model. {95% CI on annualized hospitalization rate from the Andersen-Gill model. ‖Hazard ratio, 95% CI, and P value estimated from the Andersen-Gill model with robust sandwich estimates.

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  Figure 3.. Chronic kidney disease (CKD) stage change over the 12-month follow-up period in patients based on their baseline CKD stage. Improvement was defined as a change of at least on stage lower than baseline and worsened was defined as a change that was at least 1 stage higher than baseline.