Key result
Administration of the EDNO synthesis inhibitor L-NMMA led to significant and comparable increases in mean arterial pressure and decreases in renal blood flow across sham, UNX, and 5/6 NX rats (P<0.01).
Why the study?
Does inhibition of endothelium-derived nitric oxide alter hemodynamic adaptations after graded renal mass reduction in rats?
Does inhibition of endothelium-derived nitric oxide alter hemodynamic adaptations after graded renal mass reduction in rats?
p-value: p=< 0.01
Inhibition of endothelium-derived nitric oxide produces similar hemodynamic changes regardless of the degree of renal mass reduction in rats.
EDNO inhibition yields comparable hemodynamic effects across rat renal ablation models; leaves open differential nitric oxide adaptation in human CKD.
The mediator(s) of the adaptive increases in renal blood flow (RBF) and glomerular filtration rate (GFR) after renal mass reduction have not been identified. The present studies were designed to investigate the role of endothelium-derived nitric oxide (EDNO) in the hemodynamic adaptations after graded renal mass reduction. The experiments were performed in rats that had undergone a sham reduction in renal mass, uninephrectomy (UNX), or 5/6 NX (UNX plus excision of both poles of the contralateral kidney) 3-4 wk before. Measurements of RBF, GFR, renal vascular resistance (RVR), mean arterial pressure (MAP), and plasma renin concentration (PRC) were obtained before and after administration of the EDNO synthesis inhibitor NG-monomethyl-L-arginine (L-NMMA). L-NMMA (50 mg/kg bolus plus 500 micrograms.kg-1.min-1 infusion) led to significant (P < 0.01) and comparable increases in MAP (mmHg) (P < 0.01) in sham rats (117 +/- 6 to 154 +/- 6), UNX rats (112 +/- 5 to 139 +/- 7), and 5/6 NX rats (116 +/- 5 to 149 +/- 7). RVR increased significantly in all three groups (P < 0.01). The resultant decrease in RBF (ml.min-1.kg-1) was similar in sham rats (34.9 +/- 2.6 to 23.8 +/- 1.6), UNX rats (43.9 +/- 3.6 to 27.3 +/- 2.8), and 5/6 NX rats (34.6 +/- 2 to 22.3 +/- 1.6) (P < 0.01 for all groups).(ABSTRACT TRUNCATED AT 250 WORDS)
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Griffin et al. (1993) studied Renal mass reduction. NG-monomethyl-L-arginine (L-NMMA) vs. Baseline (before administration) was evaluated on Mean arterial pressure (MAP) and renal blood flow (RBF) (p=< 0.01). Administration of the EDNO synthesis inhibitor L-NMMA led to significant and comparable increases in mean arterial pressure and decreases in renal blood flow across sham, UNX, and 5/6 NX rats (P<0.01).
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