Key result
HOMA index, but not kITT, is independently associated with increased carotid intima-media thickness.
Why the study?
The independent contribution of insulin resistance to carotid atherosclerosis remains under debate.
Is insulin resistance, measured by HOMA or kITT, independently associated with carotid atherosclerosis in middle-aged white patients?
Population
1771 middle-aged white patients
Comparison
HOMA index vs kITT insulin resistance indices
Design
Cross-sectional study
Authors
Loading...
HOMA may refine carotid IMT risk beyond metabolic syndrome components; hypothesis-generating and requires prospective validation before clinical use.
Cross-Sectional (n=1,771)
Is insulin resistance, measured by HOMA or kITT, independently associated with carotid atherosclerosis in middle-aged white patients?
p-value: p=0.02
HOMA is associated with carotid IMT, but this association is largely driven by the clustered expression of metabolic syndrome components.
Sourij et al. (2008) conducted a cross-sectional in Carotid Atherosclerosis (n=1,771). Insulin resistance (HOMA and kITT indices) was evaluated on Average carotid intima media thickness (IMT) (p=0.02). The HOMA index, but not kITT, remained an independent predictor for average carotid intima media thickness after adjusting for age and metabolic syndrome components (P=0.02).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: