Key result
Patient-specific CRT simulation strongly tracks post-implant LVEF improvement with ~0.94 correlation.
Why the study?
The currently proposed criteria for identifying patients who would benefit from cardiac resynchronization therapy still need to be optimized.
Can patient-specific multi-scale heart simulation predict the clinical response to CRT in patients with heart failure and conduction block?
Observational (n=9)
Can patient-specific multi-scale heart simulation predict the clinical response to CRT in patients with heart failure and conduction block?
Effect estimate: r=0.94
p-value: p=<0.01
No takes yet. Share an insight, caveat, or question.
Patient-specific multi-scale heart simulation can successfully reproduce and predict the response to CRT, correlating simulated dP/dt max with clinical EF improvement.
Okada et al. (2017) conducted an observational in Heart failure and conduction block (n=9). Patient-specific multi-scale heart simulation vs. Actual clinical response was evaluated on Correlation between simulated maximum dP/dt and clinically observed improvement in ejection fraction (r=0.94, p=<0.01). Patient-specific multi-scale heart simulation of maximum dP/dt strongly correlated with clinically observed improvement in ejection fraction after cardiac resynchronization therapy (r=0.94, p<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: