Key result
The addition of aluminum hydroxide gel to ISA oil adjuvants in polyvalent FMD vaccines improved both cellular and humoral immune responses in cattle compared to ISA oils alone.
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May enhance FMD vaccine potency in cattle; leaves open field efficacy and durability trials.
A 2019 study studied Foot and Mouth Disease (FMD) (n=27). Polyvalent FMD vaccines with ISA oils and aluminum hydroxide gel adjuvants vs. Non-vaccinated control and ISA oil alone was evaluated on Cellular and humoral immune responses (measured by lymphocyte proliferation XTT assay and Serum Neutralization Test). The addition of aluminum hydroxide gel to ISA oil adjuvants in polyvalent FMD vaccines improved both cellular and humoral immune responses in cattle compared to ISA oils alone.
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