Key result
Switching from verapamil to captopril precipitates acute MI in severe hypertension with normal coronary arteries.
Why the study?
Verapamil is an effective antihypertensive with uncommon serious adverse effects, but its withdrawal coinciding with myocardial infarction has not been well described.
Does verapamil withdrawal cause myocardial infarction in patients with severe hypertension?
Case Report (n=1)
Does verapamil withdrawal cause myocardial infarction in patients with severe hypertension?
Verapamil withdrawal may be associated with myocardial infarction in hypertensive patients, possibly due to increased platelet or vascular alpha 2-adrenoreceptor affinity for catecholamines.
Authors
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May signal risk with abrupt verapamil withdrawal during antihypertensive switch; hypothesis-generating and leaves causal role in MI open.
Dimmitt et al. (1988) conducted a case report in Severe hypertension (n=1). Verapamil withdrawal and captopril introduction was evaluated on Myocardial infarction. Verapamil withdrawal and captopril introduction coincided with a myocardial infarction in a previously asymptomatic woman with severe hypertension and a normal coronary angiogram.
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