Key result
Diabetes linked to ~4-fold higher dyslipidemia prevalence in NAFLD.
Why the study?
NAFLD is closely correlated with dyslipidemia and type 2 diabetes, but the association between dyslipidemia and diabetes in NAFLD patients requires further investigation.
Is diabetes mellitus associated with a higher prevalence of dyslipidemia in patients with nonalcoholic fatty liver disease?
Cross-Sectional (n=65)
No
Is diabetes mellitus associated with a higher prevalence of dyslipidemia in patients with nonalcoholic fatty liver disease?
Absolute Event Rate: 63.4% vs 16.7%
p-value: p=<0.001
In patients with nonalcoholic fatty liver disease, the presence of diabetes mellitus is associated with a significantly higher prevalence of dyslipidemia.
May warrant enhanced dyslipidemia monitoring in diabetic NAFLD; leaves open causal links and intervention effects.
Background: NAFLD is a clinicopathologic syndrome that is closely correlated to visceral obesity, dyslipidemia, insulin resistance, and type 2 diabetes, thus suggesting that NAFLD is another feature of the metabolic syndrome.The pathophysiology of non-alcoholic fatty liver disease involves insulin resistance, which causes hepatic steatosis, a process enhanced in patients with type 2 diabetes mellitus and/or obesity. Materials and Methods:This study was conducted in Department of Medicine and Department of Radiology, GMC, Kannauj.This was a Cross-sectional study done over a period of 18 months.The study include admitted patients having fatty liver finding on ultrasound and patients having any history of alcohol abuse and viral hepatitis were excluded.Sample size was 65.Results: Prevalence of dyslipidemia was 63.4% among diabetics as compared to 16.7%among non-diabetics.Statistically, this difference was significant (p<0.001).Similarly, mean FBS and PP BS levels were also significantly higher among patients with dyslipidemia as compared to those not having dyslipidemia (p<0.05).Conclusion: In present study prevalence of dyslipidemia with NAFLD-diabetes mellitus in cohort was found to statistically significant (p<0.001),which emphasizes that dyslipidemia is added disadvantage to precipitate non alcoholic fatty liver disease.How to cite this article:
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Amzarul et al. (2017) conducted a cross-sectional in Nonalcoholic fatty liver disease (n=65). Diabetes mellitus vs. Non-diabetic patients was evaluated on Prevalence of dyslipidemia (p=<0.001). Among patients with nonalcoholic fatty liver disease, the prevalence of dyslipidemia was significantly higher in those with diabetes (63.4%) compared to those without diabetes (16.7%).
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