Key result
In patients with mild non-insulin dependent diabetes mellitus, the parasympathetic nerve index was significantly lower compared to healthy controls (9 vs 11 msec, p<0.05), indicating early parasympathetic dysfunction.
Why the study?
Autonomic nerve dysfunction in diabetic patients significantly impairs quality of life and affects the course and prognosis of comorbid diseases, sometimes causing sudden death.
Are there differences in autonomic nerve function as measured by Holter ECG heart rate variability between non-insulin dependent diabetic subjects at various stages and healthy controls?
Cross-Sectional (n=120)
No
Are there differences in autonomic nerve function as measured by Holter ECG heart rate variability between non-insulin dependent diabetic subjects at various stages and healthy controls?
Absolute Event Rate: 9% vs 11%
p-value: p=<0.05
Holter ECG heart rate variability analysis reveals that parasympathetic dysfunction precedes sympathetic dysfunction in the early stages of non-insulin dependent diabetes.
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Shintani et al. (1998) conducted a cross-sectional in Non-insulin dependent diabetes mellitus (NIDDM) (n=120). Mild non-insulin dependent diabetes mellitus vs. Healthy controls was evaluated on Parasympathetic nerve index (HF value in msec) (p=<0.05). In patients with mild non-insulin dependent diabetes mellitus, the parasympathetic nerve index was significantly lower compared to healthy controls (9 vs 11 msec, p<0.05), indicating early parasympathetic dysfunction.
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