Key result
Fenestra VC micro-CT provides sustained enhancement up to ~620 HU for murine cardiac phenotyping vs. Isovue-370.
Why the study?
Noninvasive imaging methods for in vivo characterization of cardiac structure and function in mice require demonstration using high-resolution micro-CT with integrated motion control.
Does simultaneous cardiac- and respiratory-gated micro-CT with contrast agents provide sufficient image quality for in vivo characterization of cardiac structure and function in mice?
Population
C57BL/6 mice
Comparison
Isovue-370 intravenous infusion vs Fenestra VC single intravenous injection
Design
Simultaneous cardiac- and respiratory-gated micro-CT imaging
Follow-up
Up to 3 hours
Authors
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May support gated micro-CT phenotyping in mice; leaves open validation and clinical translation.
Does simultaneous cardiac- and respiratory-gated micro-CT with contrast agents provide sufficient image quality for in vivo characterization of cardiac structure and function in mice?
Simultaneous cardiac- and respiratory-gated micro-CT with a blood pool contrast agent (Fenestra VC) provides sufficient image quality for noninvasive morphological and functional cardiac phenotyping in mice.
Badea et al. (2005) studied Cardiac structure and function imaging. Fenestra VC vs. Isovue-370 was evaluated on Contrast enhancement and image quality for morphological and functional studies. Micro-CT with Fenestra VC provided constant enhancement over 3 hours (maximum ~620 HU in aorta) and sufficient image quality for standardized cardiac phenotyping in mice compared to Isovue-370.
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