Key result
Oral calcium supplementation increases urinary dopamine and sodium clearance but fails to reduce 24-h BP.
Why the study?
The effect of oral calcium supplementation on renal tubular dopaminergic activity in patients with mild to moderate essential hypertension was unclear.
Does oral calcium supplementation alter blood pressure and renal tubular dopaminergic activity in patients with mild to moderate essential hypertension?
Comparison
Before and after oral calcium supplementation
Design
Cohort study
Follow-up
1 week
Authors
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Does not support calcium supplementation for BP lowering in essential hypertension; leaves open effects on renal dopaminergic activity.
Does oral calcium supplementation alter blood pressure and renal tubular dopaminergic activity in patients with mild to moderate essential hypertension?
Short-term oral calcium supplementation in essential hypertension induces natriuresis and increases renal dopaminergic activity, though it does not significantly lower blood pressure over 1 week.
Oazai et al. (1993) studied mild to moderate essential hypertension (n=15). Oral calcium supplementation was evaluated on Change in 24-h blood pressure and excretions of electrolytes and catecholamines. Oral calcium supplementation significantly increased daily urinary excretion of free dopamine and sodium clearance, but did not significantly change 24-h blood pressure.
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