What is the clinical evidence from this study?

Study design: Other. Population: Type II diabetes with hypertension and left ventricular hypertrophy. Intervention: Dietary calcium supplementation vs. Atenolol (50 mg). Primary outcome: Left ventricular mass (LVM) (p=<0.02).

What does this research mean for the field?

Dietary calcium supplementation reduces peripheral vascular resistance and induces regression of left ventricular hypertrophy in hypertensive type II diabetic Black men. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 1990American Journal of Hypertension

Dietary Calcium Induces Regression of Left Ventricular Hypertrophy in Hypertensive Non - Insulin-dependent Diabetic Blacks

Q: What are the key findings of this study?

Dietary calcium supplementation (600 mg/day) for 3 months in black hypertensive diabetic men significantly reduced left ventricular mass from 289 to 240 g (P<0.02).

Q: What does this research mean for the field?

Dietary calcium supplementation reduces peripheral vascular resistance and induces regression of left ventricular hypertrophy in hypertensive type II diabetic Black men. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Calcium supplementation reduces left ventricular mass ~17% in hypertensive diabetic men.

P<0.02

Why the study?

Dietary calcium supplementation effects on vascular resistance and left ventricular mass in type II diabetic hypertensive black men were not established.

Does calcium supplementation reduce left ventricular mass and vascular resistance in type II diabetic hypertensive black men with LVH?

Population

Seven type II diabetic hypertensive black men with LVH off antihypertensive treatment

Comparison

Calcium supplementation 600 mg/day vs atenolol 50 mg

Design

Cohort study with control group

Follow-up

3 months

Authors

MZMichael B. ZemelEpirus Biopharmaceuticals (United States)PZPaula C. ZemelEastern Michigan University RBRobert J. BrygUniversity of California, Los Angeles

Discussion

Member takes

Implication

Hypothesis-generating for LV mass reduction with calcium supplementation in this group; prospective RCTs needed before clinical adoption.

Structured PICO

Does calcium supplementation reduce left ventricular mass and vascular resistance in type II diabetic hypertensive black men with LVH?

Population

Black men with type II diabetes, hypertension, and left ventricular hypertrophy, treated with calcium supplementation for 3 months.

Intervention

Calcium supplementation 600 mg per day for 3 months

Comparator

Atenolol 50 mg

Outcome

Changes in forearm blood flow (FBF), vascular resistance (FVR), and left ventricular mass (LVM) at 12 weekssurrogate

Main Result

p-value: p=<0.02

Calcium supplementation significantly reduces vascular resistance and causes partial regression of left ventricular hypertrophy in black hypertensive diabetic men.

Cite This Study

Zemel et al. (1990) studied Type II diabetes with hypertension and left ventricular hypertrophy. Dietary calcium supplementation vs. Atenolol (50 mg) was evaluated on Left ventricular mass (LVM) (p=<0.02). Dietary calcium supplementation (600 mg/day) for 3 months in black hypertensive diabetic men significantly reduced left ventricular mass from 289 to 240 g (P<0.02).

synapsesocial.com/papers/6ab8d8a7b16455caf3297e61 https://doi.org/10.1093/ajh/3.6.458

Topics

Hypertension management

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Dietary Calcium Induces Regression of Left Ventricular Hypertrophy in Hypertensive Non - Insulin-dependent Diabetic Blacks

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Topics

Dietary Calcium Induces Regression of Left Ventricular Hypertrophy in Hypertensive Non - Insulin-dependent Diabetic Blacks

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider