What is the clinical evidence from this study?

Study design: Case Report. Population: Rosuvastatin-associated rhabdomyolysis and acute kidney injury (n=1). Intervention: Rosuvastatin. Primary outcome: Clinical and renal recovery.

What does this research mean for the field?

Rosuvastatin therapy can induce severe rhabdomyolysis leading to dialysis-requiring acute kidney injury in elderly patients. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To report a case of severe rosuvastatin-associated rhabdomyolysis causing stage 3 dialysis-requiring acute kidney injury in an octogenarian and describe clinical recovery.

September 28, 2026American Journal of Case ReportsOpen Access

Severe Rosuvastatin-Associated Rhabdomyolysis and Dialysis-Requiring Acute Kidney Injury in an Octogenarian Patient: A Case Report

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Key result

Prompt rosuvastatin cessation, fluids, and hemodialysis enable substantial renal recovery in severe statin-associated rhabdomyolysis.

Authors

LMLuiza Mendonça Pessoa De Melo MPMauro de Deus PassosUniversidade de Brasília DFDilson Palhares FerreiraSociety of Hematologic Oncology

Discussion

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Implication

Case report demonstrates dialysis-requiring acute kidney injury from rosuvastatin-associated rhabdomyolysis in an octogenarian, highlighting renal recovery after prompt drug cessation and...

Key Points

To report a case of severe rosuvastatin-associated rhabdomyolysis causing stage 3 dialysis-requiring acute kidney injury in an octogenarian and describe clinical recovery.
Evaluated an 87-year-old patient (N=1) who developed severe muscle breakdown and renal failure 20 days after initiating rosuvastatin and ezetimibe.
Assessed adverse drug causality using the 10-item Naranjo Adverse Drug Reaction Probability Scale.
Managed the patient with immediate statin cessation, intravenous volume resuscitation, and hemodialysis support.
Laboratory testing confirmed severe rhabdomyolysis with massive creatine kinase elevation (> 4267 U/L), along with AST of 419 U/L and ALT of 342 U/L.
The Naranjo probability score was 5, categorizing rosuvastatin as the probable causative agent in the setting of geriatric polypharmacy and dehydration.
Prompt intervention enabled dialysis independence and functional recovery, with serum creatinine stabilizing at 1.40 mg/dL compared to a baseline of 1.00 mg/dL.

Study Design

Type

Case Report (n=1)

Multicenter

PICO

Population

An 87-year-old woman with polypharmacy who developed severe rhabdomyolysis and stage 3 acute kidney injury requiring hemodialysis 20 days after starting rosuvastatin.

Exposure / Comparator

Rosuvastatin (20 mg/day)

Primary Outcome

Clinical and renal recovery

Limitations

Derived from a single patient with multiple baseline vulnerabilities and overlapping risk factors.
Causal attribution remains probable rather than definitively established due to polypharmacy and concurrent interventions.
Serum rosuvastatin concentrations were not measured during routine care.
Rechallenge or placebo testing was not performed.

Cite This Study

Melo et al. (2026) conducted a case report in Rosuvastatin-associated rhabdomyolysis and acute kidney injury (n=1). Rosuvastatin was evaluated on Clinical and renal recovery. Prompt discontinuation of rosuvastatin, fluid resuscitation, and hemodialysis led to substantial renal and functional recovery in an 87-year-old woman with severe statin-associated rhabdomyolysis.

synapsesocial.com/papers/6ab9b4217822ec8fc3d8d8f4 https://doi.org/10.12659/ajcr.954160

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Implication

Case report demonstrates dialysis-requiring acute kidney injury from rosuvastatin-associated rhabdomyolysis in an octogenarian, highlighting renal recovery after prompt drug cessation and...

Severe Rosuvastatin-Associated Rhabdomyolysis and Dialysis-Requiring Acute Kidney Injury in an Octogenarian Patient: A Case Report

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Limitations

Cite This Study

Severe Rosuvastatin-Associated Rhabdomyolysis and Dialysis-Requiring Acute Kidney Injury in an Octogenarian Patient: A Case Report

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Limitations

Cite This Study

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