Key result
Amiodarone causes reversible leukocytoclastic vasculitis and polyserositis in a dose-dependent case report.
Why the study?
High doses of amiodarone have been recently proposed for resistant cardiac arrhythmias, but dose-dependent adverse effects such as vasculitis and polyserositis may occur.
Does amiodarone cause vasculitis and polyserositis in patients with resistant supraventricular tachycardias?
Case Report (n=1)
Does amiodarone cause vasculitis and polyserositis in patients with resistant supraventricular tachycardias?
High doses of amiodarone can cause dose-dependent adverse effects such as cutaneous leukocytoclastic vasculitis and polyserositis, which resolve upon discontinuation.
May warrant considering amiodarone in the differential for unexplained vasculitis or polyserositis; this Level 5 case leaves open questions of incidence and causality.
A dose-dependent cutaneous leukocytoclastic vasculitis developed in a 34 year old man who was given amiodarone for supraventricular tachycardias resistant to other drugs. This adverse reaction disappeared within 2 weeks after discontinuation of amiodarone despite its very long half-life of 52 days in this patient. During previous treatment periods with amiodarone, the patient had experienced photosensitivity and dose-dependent polyserositis. Since high doses of amiodarone have been recently proposed for the treatment of resistant cardiac arrhythmias, dose-dependent adverse effects as described here may be encountered with increasing frequency.
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Stäubli et al. (1985) conducted a case report in Supraventricular tachycardias resistant to other drugs (n=1). Amiodarone was evaluated on Development of cutaneous leukocytoclastic vasculitis and polyserositis. Amiodarone administration in a 34-year-old man caused dose-dependent cutaneous leukocytoclastic vasculitis and polyserositis, which resolved within 2 weeks of drug discontinuation.
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