Key result
Prolonged amiodarone therapy causes dermatological complications, primarily phototoxic reactions and hyperpigmentation, in up to 75% of patients.
Why the study?
What are the cutaneous adverse reactions associated with prolonged amiodarone use?
What are the cutaneous adverse reactions associated with prolonged amiodarone use?
Dermatological complications of amiodarone are common (up to 75%), mostly reversible, and significantly impact patient quality of life despite rarely causing treatment discontinuation.
May prompt enhanced photoprotection counseling with prolonged amiodarone; leaves open incidence and prevention in contemporary cohorts.
Dermatological complications of amiodarone are commonly encountered problems in therapy. The incidence in the population of patients with prolonged use of amiodarone reaches nearly 75% according to various sources. Nevertheless, they are often misdiagnosed or overlooked. The aim of this review is to present the current state of knowledge about skin changes induced by amiodarone, including phototoxic and photoallergic reactions, as well as hyperpigmentation. In most cases, the adverse effects are reversible and disappear after discontinuation of the drug. Although the dermatological complications usually do not influence the outcome of the therapy and rarely cause discontinuation of treatment, they have a great impact on patient quality of life.
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Dariusz A. Kosior (2014) conducted a review in Amiodarone-induced cutaneous adverse reactions. Amiodarone was evaluated. Prolonged amiodarone therapy causes dermatological complications, primarily phototoxic reactions and hyperpigmentation, in up to 75% of patients.
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