July 17, 2012EP Europace
‘Intrahepatic cholestatic hepatitis following diagnostic ajmaline challenge’
Key result
Diagnostic ajmaline challenge (1 mg/kg) induced intrahepatic cholestatic hepatitis in a 54-year-old woman, with serum bilirubin peaking at 266 mmol/L.
Why the study?
Does diagnostic ajmaline challenge cause intrahepatic cholestatic hepatitis in a patient screened for Brugada syndrome?
Population
A 54-year-old woman undergoing diagnostic ajmaline challenge as screening for Brugada syndrome
Design
Case_report
Follow-up
Several months
Authors
Discussion
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Implication
Ajmaline challenge was associated with cholestatic hepatitis in one case; hypothesis-generating for pre-procedure liver testing in Brugada screening.
Study Design
Type
Case Report (n=1)
Structured PICO
Does diagnostic ajmaline challenge cause intrahepatic cholestatic hepatitis in a patient screened for Brugada syndrome?
P
Population
A 54-year-old woman who underwent diagnostic ajmaline challenge as screening for Brugada syndrome.
E
Exposure
Ajmaline 1 mg/kg
O
Outcome
Development of intrahepatic cholestatic hepatitissafety
Diagnostic ajmaline challenge for Brugada syndrome screening can cause intrahepatic cholestatic hepatitis even at low doses, suggesting the need to check liver function prior to the challenge.
Cite This Study
Mellor et al. (2012) conducted a case report in Suspected Brugada syndrome (n=1). Ajmaline challenge was evaluated on Development of intrahepatic cholestatic hepatitis. Diagnostic ajmaline challenge (1 mg/kg) induced intrahepatic cholestatic hepatitis in a 54-year-old woman, with serum bilirubin peaking at 266 mmol/L.