Key result
Diffuse myocardial fibrosis in sickle cell anemia is linked to diastolic dysfunction and elevated NT-proBNP.
Why the study?
Diffuse myocardial fibrosis is a common and underappreciated feature of sickle cell anemia that may underlie diastolic dysfunction, but its association was not well established.
Is diffuse myocardial fibrosis associated with diastolic dysfunction in patients with sickle cell anemia?
Is diffuse myocardial fibrosis associated with diastolic dysfunction in patients with sickle cell anemia?
Diffuse myocardial fibrosis measured by ECV is a common feature in sickle cell anemia and appears to be a novel mechanism underlying diastolic dysfunction.
Supports myocardial fibrosis as contributor to diastolic dysfunction in sickle cell anemia; hypothesis-generating and requires prospective validation.
= .001). In conclusion, diffuse myocardial fibrosis, determined by ECV, is a common and previously underappreciated feature of SCA that is associated with diastolic dysfunction, anemia, and high NT-proBNP. Diffuse myocardial fibrosis is a novel mechanism that appears to underlie diastolic dysfunction in SCA.
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Niss et al. (2017) studied this question. Diffuse myocardial fibrosis is a common feature of sickle cell anemia that is associated with diastolic dysfunction, anemia, and high NT-proBNP.
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