Key result
Apelin-12 levels are linked to CK-MB activity and reperfusion success in STEMI patients.
Why the study?
The association between apelin-12 levels and creatine kinase-MB activity in predicting reperfusion success in STEMI patients was unclear.
Is apelin-12 level associated with creatine kinase-MB activity in predicting the effectiveness of reperfusion therapy in STEMI patients?
Observational (n=72)
Is apelin-12 level associated with creatine kinase-MB activity in predicting the effectiveness of reperfusion therapy in STEMI patients?
Apelin-12 levels measured 12 hours post-reperfusion are associated with CK-MB activity and may help predict reperfusion success in STEMI patients.
Apelin-12 may support reperfusion assessment in STEMI; leaves open incremental value over CK-MB pending prospective validation.
BACKGROUND: Acute myocardial infarction is characterised by an imbalance in the supply and demand of oxygen in the heart. It requires urgent reperfusion, and poor outcomes are attributed to myocardial ischaemia-reperfusion injury. We aimed to evaluate the association between apelin-12 levels and creatine kinase-MB activity in predicting the effectiveness of reperfusion therapy in ST-segment elevation myocardial infarction (STEMI) patients. METHODS: In this study we included 72 patients with the following criteria: chest pain suggestive of myocardial ischaemia for at least 30 minutes, an electrocardiogram with ST-segment elevation (measured at the J-point) ≥ 2 mm in leads V2-V3 and/or ≥ 1 mm in the other leads, rise of specific biomarkers such as cardiac troponin and the MB fraction of creatine kinase (CK-MB), and those who underwent reperfusion therapy. Blood samples for the measurement of apelin-12 and creatine kinase-MB were collected 12 hours after the reperfusion therapy. RESULTS: = 0.86). CONCLUSION: In STEMI patients undergoing reperfusion therapy, Apelin-12 level was associated with creatine kinase-MB activity according to the success of the reperfusion.
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Krasniqi et al. (2024) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=72). Apelin-12 levels was evaluated on Creatine kinase-MB activity and effectiveness of reperfusion therapy. In STEMI patients undergoing reperfusion therapy, apelin-12 levels were associated with creatine kinase-MB activity according to the success of the reperfusion.
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