Key result
Gastric cancer-associated PTTM presents as unexplained acute dyspnea and severe pulmonary hypertension.
Why the study?
Pulmonary tumour thrombotic microangiopathy is a rare, rapidly progressive, and fatal pulmonary complication of malignancy that requires consideration in differential diagnosis of unexplained dyspnoea and pulmonary hypertension.
Case Report (n=1)
PTTM should be considered in the differential diagnosis of dyspnea of unknown origin, particularly with respiratory failure, pulmonary hypertension, and lack of response to steroids.
Consider PTTM in unexplained subacute respiratory failure with pulmonary hypertension; case report leaves open optimal diagnostic approaches for occult malignancy.
Pulmonary tumour thrombotic microangiopathy (PTTM) is a rapidly progressive pulmonary disease that is a fatal complication of malignancy. It manifests clinically as subacute respiratory failure with pulmonary hypertension, progressive right sided heart failure, and sudden death. We describe here a case of PTTM associated with occult metastatic signet ring cell carcinoma of the stomach. Although rare, PTTM needs to be considered in the differential diagnosis of dyspnoea of unknown origin, particularly in patients with respiratory failure and also pulmonary hypertension, and in patients were there is no improvement in respiratory symptoms with steroid therapy.
No takes yet. Share an insight, caveat, or question.
McAnearney et al. (2015) conducted a case report in Pulmonary tumour thrombotic microangiopathy (PTTM) (n=1). A case of pulmonary tumour thrombotic microangiopathy associated with occult metastatic signet ring cell carcinoma of the stomach highlights the need to consider PTTM in unexplained dyspnea.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: