Vital Capacity and Congestive Heart Failure
Key result
Low vital capacity linked to up to ~10-fold higher risk of incident heart failure.
- n=5,209
Why the study?
The utility of vital capacity measurement in predicting congestive heart failure before overt symptoms and signs was uncertain.
Does vital capacity predict the incidence of congestive heart failure in susceptible persons before overt symptoms?
Population
5209 persons free of clinical myocardial decompensation evaluated over 18 years
Comparison
Low versus higher vital capacity standardized for height
Design
Cohort study
Follow-up
18 years
Authors
Discussion
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Member takes
Implication
May flag impending heart failure in susceptible persons; leaves open whether routine use improves outcomes today.
Study Design
Type
Cohort (n=5,209)
Structured PICO
Does vital capacity predict the incidence of congestive heart failure in susceptible persons before overt symptoms?
P
Population
5,209 persons free of clinical evidence of myocardial decompensation evaluated over an 18-year period.
E
Exposure
Vital capacity measurement (standardized for height)
C
Comparator
Higher versus lower vital capacity
O
Outcome
Incidence of clinically overt myocardial decompensation (congestive heart failure) over the next two yearshard clinical
A low or recently falling vital capacity is an independent predictor of incident congestive heart failure, suggesting its utility as a simple, noninvasive screening tool for failing left ventricular performance.
Cite This Study
Kannel et al. (1974) conducted a cohort in Congestive heart failure (n=5,209). Low vital capacity vs. Higher vital capacity was evaluated on Incidence of clinically overt myocardial decompensation. A low vital capacity was associated with up to a 10-fold increased risk of congestive heart failure, with the risk doubling in men and tripling in women at high risk.