Key result
One-hour postload glucose ≥155 mg/dL is linked to impaired GLS and increased oxidative stress.
Why the study?
The correlation between oxidative stress and subclinical myocardial damage in patients with different glycometabolic phenotypes, including NGT with elevated one-hour plasma glucose, was unclear.
Does a 1-hour post-load plasma glucose ≥155 mg/dl in normal glucose tolerant patients correlate with increased oxidative stress and subclinical myocardial damage compared to other glycometabolic phenotypes?
Cross-Sectional (n=100)
Single-blind
No
Does a 1-hour post-load plasma glucose ≥155 mg/dl in normal glucose tolerant patients correlate with increased oxidative stress and subclinical myocardial damage compared to other glycometabolic phenotypes?
p-value: p=0.001
Normal glucose tolerant patients with 1-hour post-load glucose ≥155 mg/dl exhibit early subclinical myocardial dysfunction and increased oxidative stress similar to patients with impaired glucose tolerance.
May flag early cardiac risk in normoglycemia; hypothesis-generating and requires prospective validation before practice change.
Background: The aim of the present study was to evaluate the possible correlation between oxidative stress and subclinical myocardial damage, assessed with speckle tracking echocardiography (STE), in normal glucose tolerant (NGT) patients with one-hour plasma glucose values ≥155 mg/dl (NGT≥155), comparing them to NGT<155 subjects, impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) newly diagnosed patients. Methods: We enrolled 100 Caucasian patients (mean age 61.4±10.7). All subjects underwent OGTT. The serum values of oxidative stress markers (8-isoprostane and Nox-2) were assessed with ELISA test. Echocardiographic recordings were performed using an E-95 Pro ultrasound system. Results: We observed significant differences, among the four groups, for fasting plasma glucose (p<0.0001), one-hour postload (p<0.0001), two-hours postload plasma glucose (p<0.0001). As compared with NGT<155, NGT≥155 exhibited significantly worse insulin sensitivity and higher values of hs-CRP. No significant differences were observed between NGT≥155 and IGT patients. There was a significant increase in 8-isoprostane (p<0.0001) and Nox-2 (p<0.0001), from the first to fourth group, indicating an increase in oxidative stress with the worsening of the metabolic status. Serum levels of 8-isoprostane and Nox-2 were significantly increased in NGT≥155 compared to NGT<155 group, but similar to IGT. The Global Longitudinal Strain (GLS), appeared progressively lower proceeding from NGT<155 to T2DM group (p<0.0001). For similar values of left ventricular ejection fraction (LVEF), NGT≥155 exhibited reduced GLS compared to NGT<155 (p=0.001), but similar to IGT patients. Conclusions: Our study demonstrated that NGT≥155 subjects exhibit early functional impairment of myocardial contractile fibres, and these alterations are correlated with increased oxidative stress.
No takes yet. Share an insight, caveat, or question.
Cassano et al. (2022) conducted a cross-sectional in Hypertension with different glycometabolic phenotypes (n=100). One-hour postload plasma glucose ≥ 155 mg/dl (NGT ≥ 155) vs. One-hour postload plasma glucose < 155 mg/dl (NGT < 155) was evaluated on Global Longitudinal Strain (GLS) (p=0.001). Normal glucose tolerant patients with one-hour postload plasma glucose ≥ 155 mg/dl exhibited significantly reduced global longitudinal strain (p=0.001) and increased oxidative stress compared to those with < 155 mg/dl.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: