Key result
CRT in octogenarians is linked to higher mortality despite similar clinical improvements to younger patients.
Why the study?
The effects of cardiac resynchronization therapy in patients aged 80 years or older compared to younger patients were not well established.
Does cardiac resynchronization therapy provide similar clinical, functional, and survival benefits in patients aged >=80 years compared to those <80 years?
Population
1181 CRT patients including 85 aged ≥80 years in Italy
Comparison
CRT in patients aged ≥80 years vs <80 years
Design
National observational registry cohort study
Follow-up
12 months for clinical and functional parameters; survival follow-up duration not specified
Authors
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Supports CRT consideration in selected octogenarians; extends observational data but leaves randomized survival benefit open.
Observational (n=1,181)
Yes
Does cardiac resynchronization therapy provide similar clinical, functional, and survival benefits in patients aged >=80 years compared to those <80 years?
Absolute Event Rate: 15% vs 13%
p-value: p=0.015
Cardiac resynchronization therapy provides similar clinical, functional, and reverse remodeling benefits in very elderly patients (>=80 years) compared to younger patients, despite a higher expected all-cause mortality.
Achilli et al. (2007) conducted an observational in Heart failure (n=1,181). Age ≥80 years vs. Age <80 years was evaluated on All-cause mortality (p=0.015). Among patients receiving cardiac resynchronization therapy, those aged ≥80 years had higher all-cause mortality (15% vs 13%, P=0.015) but similar clinical improvements compared to patients <80 years.
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