Key result
Counterpulsation fails to improve collateral coronary circulation in acute LAD occlusion.
Why the study?
The effect of counterpulsation on collateral circulation after acute occlusion of the left anterior descending coronary artery was unclear.
Does not support acute collateral augmentation by counterpulsation; leaves open effects of longer duration or in clinical ischemia.
The effect of counterpulsation on collateral circulation was studied in dogs after acute occlusion of the left anterior descending coronary artery. The post mortem coronary angiograms showed clear anastomoses between the left anterior descending coronary artery and other coronary branches, but no significant changes in peripheral coronary pressure (PCP) and only minimal changes in 133Xe-clearance could be demonstrated after 3 hr of counterpulsation. Consequently, the pre-existent interarterial anastomoses apparently do not increase in diameter by counterpulsation. Possible useful effects of counterpulsation described by other authors probably cannot be explained on the basis of improved collateral blood flow.
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Reneman et al. (1972) studied Acute occlusion of the left anterior descending coronary artery. Counterpulsation was evaluated on Collateral circulation (peripheral coronary pressure and 133Xe-clearance). Counterpulsation for 3 hours in dogs with acute LAD occlusion produced no significant changes in peripheral coronary pressure and only minimal changes in 133Xe-clearance.
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