November 30, 2022European Heart Journal - Quality of Care and Clinical Outcomes
Waiting times of women vs. men undergoing transcatheter aortic valve implantation
Key result
Female sex is linked to ~51% lower odds of MR improvement after TAVR.
- OR 0.49
- 95% CI 0.27-0.90
- P=0.022
- n=344
Population
407 patients undergoing TAVI for severe aortic stenosis at a tertiary referral hospital in Australia
Comparison
Women vs men undergoing TAVI
Design
Prospective cohort study with matched cohorts
Follow-up
30 days
Authors
Discussion
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Implication
Women may have less MR improvement after TAVR; hypothesis-generating for sex-specific strategies and prospective trials.
Study Design
Type
Observational (n=344)
Multicenter
No
PICO
P
Population
344 patients (mean age 81.9 years, 48.5% female) with severe aortic stenosis and moderate to severe mitral regurgitation undergoing TAVR, followed for up to 3 years.
E
Exposure / Comparator
Female sex vs Male sex
O
Primary Outcome
Improvement of mitral regurgitation to mild or less at first postprocedural echocardiogram — OR 0.49 (0.27-0.90), p=0.022
Main Result
Odds Ratio: 0.49 (95% CI 0.27–0.9)
Absolute Event Rate: 46.2% vs 53.8%
p-value: p=0.022
Limitations
- Retrospective, observational design
- Etiology of mitral regurgitation (primary vs functional) was not routinely collected
- Mitral regurgitation severity was graded without independent blinded review
- Did not systematically ascertain which patients underwent subsequent mitral valve intervention
Cite This Study
Stehli et al. (2022) conducted an observational in Severe aortic stenosis with concomitant moderate to severe mitral regurgitation (n=344). Female sex vs. Male sex was evaluated on Improvement of mitral regurgitation to mild or less at first postprocedural echocardiogram (OR 0.49, 95% CI 0.27-0.90, p=0.022). Female sex was independently associated with lower odds of mitral regurgitation improving to mild or less following transcatheter aortic valve replacement compared to male sex (OR 0.49).