Key result
Non-right dominant coronary anatomy links to severe coronary stenosis in females, especially in the LCx.
Why the study?
The relationship between gender-specific coronary artery dominance patterns and the severity of coronary artery stenosis remains poorly understood.
Is non-right coronary artery dominance associated with increased severity of coronary artery stenosis and calcium score in male and female patients undergoing CCTA?
Cross-Sectional (n=1,115)
No
Is non-right coronary artery dominance associated with increased severity of coronary artery stenosis and calcium score in male and female patients undergoing CCTA?
p-value: p=0.009
Non-right coronary artery dominance is associated with significant coronary stenosis specifically in females, highlighting a gender-specific anatomical risk factor for coronary artery disease.
Non-right dominant patterns may signal higher stenosis risk in females on CCTA; leaves open whether dominance informs risk stratification or requires prospective validation.
Background: Coronary artery disease (CAD) is one of the leading causes of death worldwide. Several preliminary studies suggest that certain dominance patterns may be associated with the distribution and severity of stenosis, influencing the risk of cardiac complications and interventional strategies. However, the relationship of gender specific between coronary artery dominance patterns and the severity of stenosis remains poorly understood. This study designed to evaluate the relationship between gender specific, coronary artery dominance, and severity of coronary artery stenosis, number of stenosis vessels, stenosis location, and calcium score on CCTA examination. Methods: A retrospective cross-sectional study with consecutive non-probability sampling was conducted over a one-year period with 1115 patients who underwent CCTA were analysed using the Chi-square test, Fisher’s exact test, and T-test according to the type of data. Result: The result showed a strong association was found between non-right dominant coronary artery (non-RDCA) in females and significant coronary stenosis (p=0.009), with the most strongly associated location being the LCX (p=0.017). Conclusions: These findings suggest the presence of gender- and dominance-specific patterns in coronary artery disease (CAD), warranting further investigation using prospective study designs and larger sample sizes.
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Kurniawan et al. (2026) conducted a cross-sectional in Coronary artery stenosis (n=1,115). Non-right dominant coronary artery (non-RDCA) vs. Right-dominant coronary artery (RDCA) was evaluated on Significant coronary artery stenosis (>50%) (p=0.009). Non-right dominant coronary artery patterns in females were significantly associated with severe coronary artery stenosis (p=0.009), particularly in the left circumflex artery (p=0.017).
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