Key result
Acidosis stimulates sympathoadrenal activation and raises plasma catecholamines in experimental hemorrhagic shock.
Why the study?
The role of acidosis in stimulating the sympatho-adrenal system during shock and cardiopulmonary bypass has been less well elucidated.
Answers are grounded in this paper and cite their sources.
Acidosis may trigger catecholamine release in shock; hypothesis-generating and needs prospective validation before clinical use.
Stimulation of the the sympatho-adrenal system and catecholamine production are induced by several factors accompanying shock. The role of hypotension in evoking this response has been thoroughly investigated. Stimulation of epinephrine and norepinephrine in response to shock has been previously documented, both in experimental work and in clinical situations.1The important role of acidosis has been less well elucidated. This report summarizes recent work in this institution, related to the role of acidosis in the stimulation of a sympathoadrenal system, as measured by plasma catecholamine levels. Three experimental models were studied to elucidate clinical observations made during cardiopulmonary bypass. The first series of experiments previously reported by Manger et al2were designed to elucidate the effects of acid-base control on the sympathoadrenal response following irreversible hemorrhagic shock. Shock was produced in mongrel dogs with the preparation described by Wiggers,3with maintenance of mean arterial-blood pressure of 50
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J R Malm (1966) studied Shock and acidosis during cardiopulmonary bypass. Acidosis was evaluated on Plasma catecholamine levels. The role of acidosis in stimulating the sympathoadrenal system, as measured by plasma catecholamine levels, was investigated using experimental models of hemorrhagic shock.
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