Key result
Rapid ventricular pacing extends action potential duration ~51% while disrupting intercalated disc structural junctions.
Why the study?
The characteristics of the force-frequency relation under basal conditions and its responsiveness to adrenergic stimulation have not been studied in the intact, failing heart.
Population
6 pigs with severe heart failure induced by rapid LV pacing
Comparison
Basal conditions vs dobutamine infusion before and after heart failure
Design
Physiological study in conscious pigs with induced heart failure
Authors
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May inform arrhythmogenic remodeling in experimental HF; extends isolated-tissue observations but leaves translation to patients open.
Absolute Event Rate: 375.05% vs 249.04%
p-value: p=<0.001
Eising et al. (1994) studied Heart failure (n=12). High-pacing-induced heart failure vs. Sham operation was evaluated on Action potential duration of 90% repolarization (APD90) in milliseconds (p=<0.001). High-pacing-induced heart failure in dogs significantly prolonged action potential duration (375.05 vs 249.04 ms) and caused lateralization of connexin-43 and desmosome junctions compared to sham operation.
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