Key result
Higher preimplantation BNP linked to ~119% increased risk of appropriate ICD therapies.
Why the study?
The ability of preimplantation B-type natriuretic peptide and C reactive protein concentrations to predict future appropriate ICD therapies was uncertain.
Cohort (n=345)
No
Hazard Ratio: 2.19 (95% CI 1.07–4.71)
Absolute Event Rate: 27% vs 10%
p-value: p=0.040
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Preimplantation BNP was associated with appropriate ICD therapies; leaves open its utility for risk stratification or patient selection.
Verma et al. (2005) conducted a cohort in Cardiomyopathies requiring first-time ICD implantation (n=345). Preimplantation B-type natriuretic peptide (BNP) concentration above the 50th centile vs. BNP concentration below the 50th centile was evaluated on Appropriate therapies from an implantable cardioverter-defibrillator (ICD) (HR 2.19, 95% CI 1.07 to 4.71, p=0.040). Preimplantation BNP concentration above the 50th centile independently predicted appropriate ICD therapies in patients undergoing first-time implantation (HR 2.19; 95% CI 1.07-4.71; p=0.040).
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