Key result
Elevated preoperative BNP (≥1000 vs <100 pg/mL) significantly increased the risk of in-hospital mortality or cardiac arrest during ICD implantation (OR 4.25; 95% CI 2.57-7.06; P<0.001).
Why the study?
Is elevated preoperative BNP associated with increased in-hospital mortality or cardiac arrest in patients undergoing ICD implantation?
Cohort (n=53,198)
Yes
Is elevated preoperative BNP associated with increased in-hospital mortality or cardiac arrest in patients undergoing ICD implantation?
Odds Ratio: 4.25 (95% CI 2.57–7.06)
p-value: p=<0.001
Elevated preoperative BNP levels strongly and dose-dependently predict in-hospital mortality and cardiac arrest following ICD implantation.
Authors
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May flag high-BNP patients for closer monitoring during ICD implantation; leaves open whether BNP-guided strategies improve outcomes.
Wei et al. (2011) conducted a cohort in Patients undergoing implantable cardioverter-defibrillator (ICD) implantation (n=53,198). Elevated B-type natriuretic peptide (BNP) level vs. BNP <100 pg/mL was evaluated on In-hospital mortality or cardiac arrest (OR 4.25, 95% CI 2.57-7.06, p=<0.001). Elevated preoperative BNP (≥1000 vs <100 pg/mL) significantly increased the risk of in-hospital mortality or cardiac arrest during ICD implantation (OR 4.25; 95% CI 2.57-7.06; P<0.001).
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