Key result
Higher total and LMW adiponectin levels are linked to CAD in older adults.
Why the study?
The distribution of adiponectin isoforms in very old patients with or without coronary artery disease was not well characterized.
Cross-Sectional (n=108)
No
p-value: p=.008
Higher LMW-Ad in very old CAD patients should not alter care; leaves open a possible protective role requiring prospective validation.
OBJECTIVES: To study the distribution of adiponectin isoforms in a group of very old patients. DESIGN: Cross-sectional. SETTING: Geriatric ambulatory clinic of the Department of Medicine at Policlinico "Tor Vergata." PARTICIPANTS: One hundred eight elderly adults (mean age 85.0+/-3.2) with or without a history of a previous myocardial infarction as proof of established coronary artery disease (CAD) at least 3 months before entry into the study. Accordingly, subjects were divided into CAD positive (CAD+, n=50) and CAD negative (CAD-, n=58). MEASUREMENT: Assessment of adiponectin isoforms along with metabolic, lipid, and inflammatory profiles. RESULTS: CAD+ subjects had significantly higher levels of total adiponectin (Tot-Ad) and low-molecular-weight adiponectin (LMW-Ad) than CAD- subjects (P=.008 for both). LMW-Ad and high-sensitivity C-reactive protein were positively correlated, even after adjustment for waist circumference, sex, glomerular filtration rate, and presence of diabetes mellitus (correlation coefficient (r)=0.25, P=.05). This association was not confirmed when CAD+ subjects were analyzed alone. A positive association was found in CAD+ subjects between brain natriuretic peptide (BNP), high-molecular-weight adiponectin (HMW-Ad), and Tot-Ad (r=0.798 and r=0.795, P<.001 for all) but not LMW-Ad. CONCLUSION: Distribution of adiponectin isoforms differed in populations of elderly subjects according to the presence of coronary atherosclerosis. The data support the hypothesis for a protective role of LMW-Ad during aging, although additional studies are needed to definitively clarify whether LMW-Ad plays a protective role in older people with a history of CAD.
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Rizza et al. (2010) conducted a cross-sectional in Coronary Artery Disease (n=108). Coronary Artery Disease vs. No Coronary Artery Disease was evaluated on Total adiponectin and low-molecular-weight adiponectin levels (p=.008). Elderly subjects with coronary artery disease had significantly higher levels of total and low-molecular-weight adiponectin compared to those without the disease (P=.008 for both).
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