Key result
Greater LV apical thickness is linked to higher hs-cTnT and NT-proBNP in apical HCM.
Why the study?
Apical hypertrophic cardiomyopathy is a rare variant that can mimic acute coronary syndrome symptoms and repolarization disturbances, creating diagnostic challenges.
Observational (n=267)
No
Effect estimate: Beta 1.182 (95% CI 0.299-2.064)
p-value: p=0.009
Apical thickness may signal myocardial stress in apical HCM; hypothesis-generating for risk stratification, prospective validation required.
Apical hypertrophic cardiomyopathy is a rare variant of hypertrophic cardiomyopathy. It is characterized by a local hypertrophy of the apical segments and displays typical electrocardiographic and imaging patterns. The clinical manifestations are variable and range from an asymptomatic course to sudden cardiac death. The most frequent symptom is chest pain and thus apical hypertrophic cardiomyopathy can mimic the symptoms and repolarization disturbances indicative of acute coronary syndrome.
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Abdin et al. (2015) conducted an observational in Apical hypertrophic cardiomyopathy (n=267). Left ventricular apical thickness (LVA) was evaluated on hs-cTnT level (Beta 1.182, 95% CI 0.299-2.064, p=0.009). Left ventricular apical thickness was an independent predictor of elevated hs-cTnT levels (Beta 1.182) and NT-proBNP levels in patients with apical hypertrophic cardiomyopathy.
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