Myoglobin in Myocardial Infarction

Q: What are the key findings of this study?

Serum myoglobin levels strongly correlated with the extent of late gadolinium enhancement on cardiac MRI (rs = 0.73) and a cutoff of ≥ 87 μg/L identified acute myocarditis with 85% accuracy.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Acute myocarditis (n=66). Intervention: Serum myoglobin vs. MINOCA controls / High-sensitivity troponin T. Primary outcome: Correlation between serum myoglobin levels and percentage of late gadolinium enhancement (LGE) on CMR (rs = 0.73, 95% CI 0.51-0.87, p=<0.001).

Q: What does this research mean for the field?

Serum myoglobin can be elevated early in the course of myocardial infarction even when total creatine kinase levels are normal. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Lawrence J. Kagen

doi:10.7326/0003-4819-88-5-716_3

May 1, 1978Annals of Internal Medicine

Myoglobin in Myocardial Infarction

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Key result

Serum myoglobin correlates with CMR LGE and identifies acute myocarditis with ~85% accuracy.

rs = 0.73
95% CI 0.51-0.87
P<0.001
n=66

Why the study?

Assessment of myoglobin may provide additional diagnostic information in early myocardial infarction when total creatine kinase values are normal.

Study Design

Type

Cohort (n=66)

Multicenter

No

PICO

P

Population

66 patients (44 with acute myocarditis and 22 controls with MINOCA) with recent symptom onset, evaluated to determine the correlation between routine cardiac markers and late gadolinium enhancement on cardiac MRI.

E

Exposure / Comparator

Serum myoglobin vs MINOCA controls / High-sensitivity troponin T

O

Primary Outcome

Correlation between serum myoglobin levels and percentage of late gadolinium enhancement (LGE) on CMR — rs = 0.73 (0.51-0.87), p=<0.001

Main Result

Effect estimate: rs = 0.73 (95% CI 0.51-0.87)

p-value: p=<0.001

Limitations

Retrospective, single-center study design
Small sample size
Diagnosis of myocarditis was based on clinical presentation and CMR without definitive tissue diagnosis via endomyocardial biopsy in all patients

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

May aid noninvasive myocarditis evaluation; leaves open prospective validation before practice change.

Abstract

Letters and Corrections1 May 1978Myoglobin in Myocardial InfarctionLAWRENCE J. KAGEN, M.D., STEPHEN SCHEIDT, M.D.LAWRENCE J. KAGEN, M.D.Search for more papers by this author, STEPHEN SCHEIDT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-5-716_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: With regard to the article by Dr. Roberts in the December issue (Ann Intern Med 87:788-789, 1977) on the comparative values of MB-creatine kinase and myoglobin in patients with myocardial infarction, it might be worthwhile pointing out some areas where assessment of myoglobin can be of particular help or interest to the physician.1. There are occasions when patients who are early in the course of myocardial infarction may have increased levels of serum myoglobin with normal total creatine kinase values. In our study (1), five of 13 patients had this presentation. Further, the small size of...References1. KAGENSCHEIDTBUTT LSA: Serum myoglobin in myocardial infarction: the "staccato phenomenon." Is acute myocardial infarction in man an intermittent event? Am J Med 62:86-92, 1977 CrossrefMedlineGoogle Scholar2. KAGENSCHEIDTROBERTSPORTERPAUL LSLAH: Myoglobinemia following acute myocardial infarction. Am J Med 58:177-182, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hospital for Special Surgery New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMyoglobin for Detection of High-Risk Patients with Acute MyocarditisClinical Presentation and Laboratory Findings in Men Versus Women with MyocarditisMyoglobin and creatine kinase rates of release during acute myocardial infarction 1 May 1978Volume 88, Issue 5Page: 716-716KeywordsCreatine kinaseMyocardial infarction Issue Published: 1 May 1978 PDF DownloadLoading ...

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Cite This Study

Lawrence J. Kagen (1978) conducted a cohort in Acute myocarditis (n=66). Serum myoglobin vs. MINOCA controls / High-sensitivity troponin T was evaluated on Correlation between serum myoglobin levels and percentage of late gadolinium enhancement (LGE) on CMR (rs = 0.73, 95% CI 0.51-0.87, p=<0.001). Serum myoglobin levels strongly correlated with the extent of late gadolinium enhancement on cardiac MRI (rs = 0.73) and a cutoff of ≥ 87 μg/L identified acute myocarditis with 85% accuracy.

synapsesocial.com/papers/6ac4a960e36270873a49864e https://doi.org/10.7326/0003-4819-88-5-716_3

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Myoglobin in Myocardial Infarction

Study Design

PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Myoglobin in Myocardial Infarction

Study Design

PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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