Key result
Novel CAD/CAM-designed perfusion circuit reliably delivers quantifiable pulsatile hemodynamics across ~75 carotid segments.
Why the study?
An in vitro perfusion circuit capable of stimulating pulsatile peripheral vascular hemodynamics with reliable cycle-to-cycle delivery was needed.
Reliable cam-driven pulsatile perfusion may advance ex vivo vascular research; leaves open clinical translation.
An in vitro perfusion circuit is described that is capable of stimulating pulsatile peripheral vascular hemodynamics. A novel feature of its design is the incorporation of a computer-aided design and manufacture disc cam and roller follower for delivery of pulsatile hemodynamics. To date approximately 75 canine carotids have been perfused for periods of 2-24 h. The delivery of quantifiable hemodynamics in vitro via the rotation of a cam and roller follower has been found to be highly reliable on a cycle-to-cycle basis.
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Brant et al. (1986) studied this question. CAD/CAM-designed cam disc and roller follower was evaluated on Delivery of quantifiable hemodynamics. An in vitro perfusion circuit using a CAD/CAM-designed cam disc and roller follower reliably delivered quantifiable pulsatile hemodynamics to approximately 75 canine carotids over 2-24 hours.
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