Key result
Etomidate dose-dependently improves cardiac function and reduces myocardial damage in rat ischemia-reperfusion injury.
Why the study?
Etomidate has been shown to reduce ischemia/reperfusion injury in several tissues, but its protective effects on myocardial I/R injury in rats were not fully investigated.
Caution against clinical use from rodent data alone; leaves open translation of etomidate cardioprotection to human ischemia-reperfusion injury.
BACKGROUND: Etomidate has been shown to reduce ischemia/reperfusion (I/R) injury in several tissues. Here we aimed to investigate the protective effects of etomidate on I/R injury in Sprague-Dawley (SD) rats. METHODS: Thirty rats were randomly divided into 5 groups and pretreated with saline or 0.5/1/2 mg/kg etomidate. I/R injury was induced in all groups except the sham control group. After administration with saline or 0.5/1/2 mg/kg etomidate daily for another 27 days, rats were sacrificed and the effects of etomidate were analyzed. RESULTS: Treatment with etomidate dose dependently improved echocardiography indexes, ameliorated myocardial histological alterations and reduced serum creatine kinase isoenzyme (CK-MB), myoglobin (Mb) and troponin I (cTnl) levels. Fibrosis markers transforming growth factor beta (TGF-β), alpha-smooth muscle actin (α-SMA) and fibronectin was decreased with etomidate treatment. Etomidate also decreased oxidative stress and inflammation in rats, indicated by increased superoxide dismutase (SOD) and glutathione (GSH), and reduced malondialdehyde (MDA) in myocardial tissues, as well as decreased inducible NO synthase (iNOS) and increased interleukin (IL)-10 in both serum and myocardial tissues. CONCLUSIONS: Altogether, we showed that etomidate alleviated I/R injury in rats through reduced cardiac dysfunction, fibrosis and oxidative stress. These results supported the protective role of etomidate to myocardial I/R injury.
No takes yet. Share an insight, caveat, or question.
Xie et al. (2020) studied Myocardial ischemic reperfusion injury (n=30). Etomidate vs. Saline was evaluated on Cardiac function (echocardiography indexes), myocardial injury markers, fibrosis, and oxidative stress (p=<0.05). Etomidate treatment dose-dependently improved cardiac function and reduced myocardial damage, fibrosis, oxidative stress, and inflammation in rats with myocardial ischemia-reperfusion injury.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: