Population
Rat left ventricular papillary muscle
Comparison
Etomidate in propylene glycol or ethanol vs Solvents alone (propylene glycol, ethanol)
Design
Preclinical
Authors
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Animal data suggest solvent-specific relaxation effects; leaves open clinical relevance of etomidate formulations in humans.
Etomidate has a slight positive inotropic effect per se, but its solvent propylene glycol impairs sarcoplasmic reticulum function, potentially leading to a slight negative inotropic effect under certain conditions.
Riou et al. (1990) studied this question.
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